Acute motor axonal neuropathy - Paralysis Causes & Treatments

Thursday, August 4, 2022

Acute motor axonal neuropathy

 


Acute motor axonal neuropathy (AMAN), also referred to as "Chinese paralytic syndrome," is a distinct disease entity that appears different from AIDP and poliomyelitis because of its primarily axonal involvement. Recent research documented excessive axonal degeneration without preceding demyelination and suggested that the target antigen may lie on the axon. AMAN has been described, particularly during the summer months, among children and young adults in northern China and has also been reported in Mexico, Spain, India (recently described as "Asian paralysis syndrome"), Pakistan, and South Korea. Characteristic features of AMAN include fulminant and widespread paralysis with slow and usually incomplete recovery, bilateral facial weakness, frequent involvement of the tongue, normal sensory perception, and normal cerebrospinal fluid cell count.