Acute motor
axonal neuropathy (AMAN), also referred to as "Chinese paralytic
syndrome," is a distinct disease entity that appears different from AIDP
and poliomyelitis because of its primarily axonal involvement. Recent research
documented excessive axonal degeneration without preceding demyelination and
suggested that the target antigen may lie on the axon. AMAN has been described,
particularly during the summer months, among children and young adults in
northern China and has also been reported in Mexico, Spain, India (recently described
as "Asian paralysis syndrome"), Pakistan, and South Korea. Characteristic
features of AMAN include fulminant and widespread paralysis with slow and
usually incomplete recovery, bilateral facial weakness, frequent involvement of
the tongue, normal sensory perception, and normal cerebrospinal fluid cell
count.